limits

I need to produce large and big (very) matrices (Markov chains) for scientific purposes. I perform calculus that I put in a list of 20301 elements (=one row of my matrix). I need all those data in memory to proceed next Markov step but i can store them elsewhere (eg file) if needed even if it will slow my Markov chain walk-through. My computer (scientific lab): Bi-xenon 6 cores/12threads each, 12GB memory, OS: win64