.net-assembly

Could not load file or assembly or one of its dependencies. Access is denied. The issue is random, but after it happens once, it continues

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I have found plenty of information out there about this error: ‘ERROR: Could not load file or assembly ‘*.dll’ or one of its dependencies. Access is denied.’
But i haven’t found answer specific to my scenario.
My site is deploy on 6 different production servers, only on one server i am facing this issue. The issue is random, but after it happens once, it continues until the site is recompile by done a small modification in web.config file(i know trick, after modification in web.config recompile the web application) and site on that server start working.
Yesterday, issue was reproducing after one month period of working.
We can’t afford this issue on production.
Issue detail:

Can’t load System.Web.Cors assembly after call to Microsoft.Owin.Cors

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When I check the System.Web.Cors assembly reference in the Solution Explorer, the Version is 5.2.3.0. The Specific Version property is set to False. The path is to the local project bin folder. When checking the .dll properties from the File Explorer, the file’s product version and file version. is also 5.2.3.

How to separate model, view and controller in an ASP.NET MVC app into different assemblies

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At the moment I am trying to get into the ASP.NET MVC framework.
For most of my test applications I used a single assembly/project. This worked fine for some smaller applications. Then I wondered how I could place my model, controller and view classes into separate assemblies? In really big web-applications it is not very realistic to put everything into a single assembly/project.