Is there a way to simulate a “Close” event on various windows using the terminal?

I answered on Ask Ubuntu Quit all instances of gnome-terminal via a command but as you all can read gnome-terminal didn’t seems to have a SIGcall I could use to simulate this “Close” event. So this lead me to ask, is there a way in GNOME/KDE/LXDE/{put your window/desktop manager/environment here} to simulate the “Click in close button” event? I have read different questions that could have any relation to this, but don’t answer this.

How can I have more than one possibility in a script’s shebang line?

I’m in a bit of an interesting situation where I have a Python script that can theoretically be run by a variety of users with a variety of environments (and PATHs) and on a variety of Linux systems. I want this script to be executable on as many of these as possible without artificial restrictions. Here are some known setups: